Endocrine Abstracts

Cushing’s disease is the main cause of endogenous hypercortisolism. Comorbidities increase morbidity and mortality and the treatment is fundamentally surgical. Patients may use drugs to lower hypercortisolism as pre-surgical preparation and post-surgical treatment when cure is not reached.Objective: Evaluate the benefits and collateral effects of ketoconazole in Cushing’s disease.Methods: In 22 patients with Cushing’...

Objective: A prospective study to research the relationship between initial levels of prolactin in the development and outcome of patients with gestational trophoblastic disease.Material and method: A longitudinal study including 51 women attending the Reference Center of Gestational Trophoblastic Neoplasia of Rio de Janeiro- Brazil, with complete mole, and comproved histopatologic examination. All women were followed up until remission was achieved. The...

Paragangliomas and Pheochromocytomas are tumors originated from chromaffin cells (Pheochromocytomas (PHEO): adrenal glands; Paragangliomas (PGL):paravertebral thoracic, abdominal, and/or pelvic sympathetic ganglia, and glossopharyngeal and vagal neck and skull base parasympathetic ganglia). Catecholamine hypersecretion predominates in PHEO, while PGL are oligosymptomatic with compression-related symptoms. The authors report the case of a 33-year-old male with an incidental ret...

IntroductionAmong other organic functions, Prolactin (PRL) can influence metabolism.AimTo evaluate basal glucose metabolism in women with prolactinoma, according to menstrual cycle, presence of hyperprolactinemia, and dopamine agonist (DA) treatment.Material and methodsCross-sectional study of 17 women with microprolactinoma and 11 healthy controls. Variables eval...

Introduction: Pheochromocytomasand paragangliomas are tumors derived from chromaffin cells which result from mutations of at least six different genes as autosomal dominant disorders.Aim: To evaluate the existence of correlations between genetic alterations and clinical data in 16 patients with pheochromocytomas and/or paragangliomas.Methods: From 2007 to 2009, 13 patients with pheochromocytoma [3 men, medium age 39 years (14&#8211...

Introduction: Positive radiotracer uptake by the thyroid gland can occur in PET-CT. It’s meaning has led to conflicting results mainly resulting from small studies.Objective: We aim to present a large single institution consecutive case series.Material and methods: Observational, descriptive and retrospective study of the PET-CT scans performed between the years 2000–2017. We searched the word thyroid in the computer imag...

Background: The 3-year part of this trial investigated the effect of liraglutide 3.0 mg, as an adjunct to diet+exercise, in delaying onset of T2D (primary endpoint) in adults with prediabetes and obesity (BMI ≥30 kg/m2) or overweight (≥27 kg/m2) with comorbidities.Methods: Participants were randomised 2:1 to once-daily subcutaneous liraglutide 3.0 mg or placebo plus 500 kcal/day deficit diet and 150...

Background: Von Hippel Lindau Disease (VHL) is an autosomal dominant inherited syndrome characterized by high susceptibility to the development of a wide spectrum of benign and malignant, endocrine and non-endocrine neoplasias in diverse organs of patients harboring a germline mutation in VHL tumor suppressor gene. The major clinical manifestations of VHL are brain, cerebellar and spinal cord hemangioblastoma, retinal angioma, pheochromocytoma, renal cell carcinoma an...

Introduction: Central diabetes insipidus (CDI) occurs due to deficient secretion of arginine vasopressin (AVP) or antidiuretic hormone (ADH) by the posterior pituitary. It is a rare disease with an estimated prevalence of 1:25000. CDI can be acquired or congenital, secondary to malformation or genetics. Familial CDI (genetic inheritance) is mainly autosomal dominant. More than 80 mutations in the AVP gene have been described. In hereditary CDI, the age of onset is variable. Sy...